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Cell Immunol. 2010;266(1):90-7. doi: 10.1016/j.cellimm.2010.09.002. Epub 2010 Sep 17.

Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation.

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  • 1Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA.

Abstract

Worldwide the elderly population is increasing. The elderly show deficiencies in immune function. B lymphocytes are essential elements of the immune system responsible for antibody production. This laboratory previously showed that activated human B cells isolated from young adults express cyclooxygenase-2 (Cox-2) and that Cox-2 is essential for optimal antibody responses. Recent data suggests that Cox-2 expression decreases with age in mouse bone tissue. There is no information regarding Cox-2 expression in B cells from older human subjects. We investigated the expression and activity of Cox-2 in naïve and memory B cells from older people. We show that B cells from older subjects show similar Cox-2 protein expression and activity, antibody production and proliferation compared to younger people. However, we found that activated memory B cells from older people produce higher levels of IL-6 and IL-10 compared to young adults. Therefore, the dysregulated cytokine production could contribute to immune senescence in the elderly.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20889146
[PubMed - indexed for MEDLINE]
PMCID:
PMC2966539
Free PMC Article

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