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Biochem Biophys Res Commun. 2010 Nov 12;402(2):203-8. doi: 10.1016/j.bbrc.2010.09.109. Epub 2010 Oct 1.

Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association.

Author information

  • 1Department of Clinical Genomics, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. ruben.martherus@maastrichtuniversity.nl

Abstract

Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) and glioblastoma amplified sequence (GBAS). We predicted both genes to be involved in oxidative phosphorylation. Through in vitro experiments using gene-knockdown we could indeed confirm this and furthermore we asserted CHCHD10 to play a role in complex IV activity.

Copyright © 2010. Published by Elsevier Inc.

PMID:
20888800
[PubMed - indexed for MEDLINE]
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