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Ocul Immunol Inflamm. 2010 Dec;18(6):459-69. doi: 10.3109/09273948.2010.509532. Epub 2010 Oct 1.

Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.

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  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

PURPOSE:

It is speculated that retinal pigment epithelial (RPE) cells convert naïve T cells into regulatory T cells (Tregs) via soluble factors such as transforming growth factor beta (TGF-β). Yet presence or absence of similar membrane-bound mechanisms on RPE cells has yet to be addressed. Here the authors investigated the expression of surface TGF-β by RPE cells and its participation in the conversion of naive T cells into Tregs.

METHODS:

They examined the phenotype of murine CD4(+) CD25(-) T cells activated in the presence of ethanol-fixed RPE cell layers as fixation preserves membrane structure while preventing the secretion of soluble factors.

RESULTS:

Fixed RPE cells supported the development of a de novo foxp3(+) Th3-like suppressor phenotype in activated peripheral naïve T cells through an interaction that required both RPE-derived surface TGF-β, and T-cell derived TGF-β1.

CONCLUSIONS:

Aside from soluble factors, RPE-derived surface TGF-β can convert activated naïve T cells into Tregs.

PMID:
20887202
[PubMed - indexed for MEDLINE]
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