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Thromb Haemost. 2010 Dec;104(6):1093-8. doi: 10.1160/TH10-05-0294. Epub 2010 Sep 30.

Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation.

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  • 1Sébastien Lacroix-Desmazes, INSERM UMR 872 Equipe 16, Centre de Recherche des Cordeliers, Paris, F-75006 France.


The immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.

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