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J Magn Reson Imaging. 2010 Oct;32(4):914-23. doi: 10.1002/jmri.22300.

T(1ρ) and T(2) quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures.

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  • 1School of Medicine, University of California, San Francisco (UCSF), San Francisco, California 94158, USA.

Abstract

PURPOSE:

To examine T(1ρ) (T1rho) and T(2) quantitative magnetic resonance imaging (MRI) in evaluating cartilage regeneration following microfracture (MFx) and mosaicplasty (MOS) cartilage resurfacing procedures.

MATERIALS AND METHODS:

Eighteen patients underwent MFx and eight patients underwent MOS to treat symptomatic focal cartilage defects. Quantitative T(1ρ) and T(2) maps were acquired at 3-6 months and 1 year after surgery. The area of resurfacing was identified, and T(1ρ) and T(2) values for the regenerated tissue (RT) and normal cartilage (NC) were acquired. RT/NC ratios were calculated to standardize absolute T(1ρ) and T(2) values. Data were prospective, cross-sectional, and nonrandomized.

RESULTS:

T(1ρ) and T(2) showed good reanalysis reproducibility for RT and NC. Significant differences between RT and NC were present following MFx at 3-6 months for T(1ρ) and T(2) values as well as following MOS at 3-6 months and 1 year for T(1ρ) values. Following MFx, the T(2) RT/NC ratio was significantly different between 3-6 months and 1 year (P = 0.02), while the T(1ρ) RT/NC ratio approached significance (P = 0.07). Following MOS, the T(1ρ) and T(2) RT/NC ratios were not significantly different between the two timepoints.

CONCLUSION:

T(1ρ) and T(2) MRI are complementary and reproducible methods for quantitatively and noninvasively monitoring regeneration of RT following MFx and MOS.

PMID:
20882622
[PubMed - indexed for MEDLINE]
PMCID:
PMC3056553
Free PMC Article

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