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Neurology. 2010 Nov 2;75(18):1617-22. doi: 10.1212/WNL.0b013e3181fb449e. Epub 2010 Sep 29.

Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency.

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  • 1Department of Neuroimmunology, UCL Institute of Neurology, University College London, Queen Square, London, UK.

Abstract

OBJECTIVES:

Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested to be a possible cause of multiple sclerosis (MS). If the presumed mechanism of venous stasis-related parenchymal iron deposition and neurodegeneration were true, then upregulation of intrathecal iron transport proteins may be expected.

METHODS:

This was a cross-sectional (n = 1,408) and longitudinal (n = 29) study on CSF ferritin levels in patients with MS and a range of neurologic disorders.

RESULTS:

Pathologic (>12 ng/mL) CSF ferritin levels were observed in 4% of the control patients (median 4 ng/mL), 91% of patients with superficial siderosis (75 ng/mL), 73% of patients with a subarachnoid hemorrhage (59 ng/mL), 10% of patients with relapsing-remitting MS (5 ng/mL), 11% of patients with primary progressive MS (6 ng/mL), 23% of patients with secondary progressive MS (5 ng/mL), and 23% of patients with meningoencephalitis (5 ng/mL). In MS, there was no significant change of CSF ferritin levels over the 3-year follow-up period.

CONCLUSION:

These data do not support an etiologic role for CCSVI-related parenchymal iron deposition in MS.

Comment in

PMID:
20881272
[PubMed - indexed for MEDLINE]
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