Leuk Res. 2011 Mar;35(3):363-8. Epub 2010 Sep 28.

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease.

D'Arena G, Laurenti L, Minervini MM, Deaglio S, Bonello L, De Martino L, De Padua L, Savino L, Tarnani M, De Feo V, Cascavilla N.

Source

IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy. giovannidarena@libero.it

Abstract

Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.

PMID:: 20880586; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Soluble CD138 serum levels are not associated with other poor prognostic markers in patients with B-chronic lymphocytic leukaemia. [Med Oncol. 2010]
Soluble CD138 serum levels are not associated with other poor prognostic markers in patients with B-chronic lymphocytic leukaemia.
Alonci A, Allegra A, Bellomo G, D'Angelo A, Penna G, Cannavò A, Musolino C. Med Oncol. 2010 Dec; 27(4):1336-9. Epub 2009 Dec 16.
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. [N Engl J Med. 2003]
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.
Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, Marcé S, López-Guillermo A, Campo E, Montserrat E. N Engl J Med. 2003 May 1; 348(18):1764-75.
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. [Blood. 2003]
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile.
Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE, Zhao H, Ibbotson RE, Orchard JA, Davis Z, et al. Blood. 2003 Jun 15; 101(12):4944-51. Epub 2003 Feb 20.
Review Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia. [Curr Oncol Rep. 2009]
Review Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia.
Jain N, Lamanna N. Curr Oncol Rep. 2009 Sep; 11(5):353-9.
Review [Research progress on prognostic markers of chronic lymphocytic leukemia]. [Zhejiang Da Xue Xue Bao Yi Xue...]
Review [Research progress on prognostic markers of chronic lymphocytic leukemia].
Mao J, Mao ZR, Zhou R. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 May; 39(3):250-6.

See reviews... See all...

Cited by 1 PubMed Central article

Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia. [Adv Hematol. 2012]
Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia.
Koehler P, Schmidt P, Hombach AA, Hallek M, Abken H. Adv Hematol. 2012; 2012:595060. Epub 2011 Aug 8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients a...
Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease.
Leuk Res. 2011 Mar ;35(3):363-8. Epub 2010 Sep 28 .

PubMed
Differential expression of CD 180 and IgM by B-cell chronic lymphocytic leukaemi...
Differential expression of CD 180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes.
Br J Haematol. 2005 Nov ;131(3):313-9.

PubMed
Angiopoietin-2 plasma dosage predicts time to first treatment and overall surviv...
Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.
Blood. 2010 Jul 29 ;116(4):584-92. Epub 2010 Apr 9 .

PubMed
International clinical recommendations on scar management.
International clinical recommendations on scar management.
Plast Reconstr Surg. 2002 Aug ;110(2):560-71.

PubMed
The long-term natural history of trachomatous trichiasis in the Gambia.
The long-term natural history of trachomatous trichiasis in the Gambia.
Invest Ophthalmol Vis Sci. 2006 Mar ;47(3):847-52.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information