Send to

Choose Destination
See comment in PubMed Commons below
Fertil Steril. 2011 Mar 15;95(4):1471-4. doi: 10.1016/j.fertnstert.2010.08.046. Epub 2010 Sep 29.

Lipopolysaccharide induces alterations in ovaries and serum level of progesterone and 17β-estradiol in the mouse.

Author information

  • 1Molecular Biology and Reproductive Immunology Laboratory, School of Studies in Biochemistry, Jiwaji University, Gwalior, India.


Our objective was to investigate the effect of gram-negative bacterial infection on the ovaries and serum level of P(4) and 17β-E(2) during the preimplantation days of pregnancy in the mouse. We found that lipopolysaccharide alters the serum level of P(4) and E(2) during the preimplantation days of pregnancy and elevates the E(2)/P(4) ratio, which may keep the uterus nonreceptive during the preimplantation days of pregnancy and also not prepare the developing blastocysts for implantation in the mouse. A large infiltration of macrophages in the corpora lutea and appearance of graafian follicles from day 3.5 of pregnancy because of lipopolysaccharide treatment, which reflect a gram-negative bacterial infection, may be responsible for ovarian dysfunction and altered P(4) and E(2) level in serum.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk