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Zhongguo Yao Li Xue Bao. 1990 May;11(3):253-7.

[Anti-arrhythmic effects of matrine].

[Article in Chinese]

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  • 1Department of Pharmacology, College of Basic Medicine, Beijing Medical University, China.


Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT. The HR was retarded and the PR and QTc intervals were prolonged.

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