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J Biol Chem. 2010 Nov 26;285(48):37359-69. doi: 10.1074/jbc.M110.172080. Epub 2010 Sep 28.

An ancient P-loop GTPase in rice is regulated by a higher plant-specific regulatory protein.

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  • 1State Key Laboratory of Agrobiotechnology and School of Life Sciences, Chinese University of Hong Kong, Shatin, Hong Kong.

Abstract

YchF is a subfamily of the Obg family in the TRAFAC class of P-loop GTPases. The wide distribution of YchF homologues in both eukarya and bacteria suggests that they are descendents of an ancient protein, yet their physiological roles remain unclear. Using the OsYchF1-OsGAP1 pair from rice as the prototype, we provide evidence for the regulation of GTPase/ATPase activities and RNA binding capacity of a plant YchF (OsYchF1) by its regulatory protein (OsGAP1). The effects of OsGAP1 on the subcellular localization/cycling and physiological functions of OsYchF1 are also discussed. The finding that OsYchF1 and OsGAP1 are involved in plant defense response might shed light on the functional roles of YchF homologues in plants. This work suggests that during evolution, an ancestral P-loop GTPase/ATPase may acquire new regulation and function(s) by the evolution of a lineage-specific regulatory protein.

PMID:
20876569
[PubMed - indexed for MEDLINE]
PMCID:
PMC2988341
Free PMC Article

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