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Biol Psychiatry. 2010 Dec 1;68(11):1061-5. doi: 10.1016/j.biopsych.2010.08.004. Epub 2010 Sep 27.

Reduced thickness of medial orbitofrontal cortex in smokers.

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  • 1Faculty of Psychology and Educational Sciences, Department of Experimental Psychology, Ghent University, Ghent, Belgium.



Structural deficiencies within the prefrontal cortex might be related to drug-taking behavior that prevails in smokers. Cortical thickness has been found to be a structural modulator of cerebral function and cognition and a subtle correlate of mental disorders. However, to date an analysis of cortical thickness in smokers compared with never-smokers has not been undertaken.


We acquired high-resolution magnetic resonance imaging scans from 22 smokers and 21 never-smokers and used FreeSurfer to model the gray-white and pial surfaces for each individual cortex to compute the distance between these surfaces to obtain a measure of cortical thickness. The main cortical folds were aligned across individuals with FreeSurfer's surface-based averaging technique to compare whole brain differences in cortical thickness between smokers and never-smokers.


Relative to never-smokers, smokers showed greater cortical thinning in the left medial orbitofrontal cortex (mOFC). Cortical thickness measures extracted from mOFC correlated negatively with the amount of cigarettes consumed/day and the magnitude of lifetime exposure to tobacco smoke.


The brains of smokers are structurally different from those of never-smokers in a dose-dependent manner. The cortical thinning in mOFC in smokers relative to never-smokers might imply dysfunctions of the brain's reward, impulse control, and decision-making circuits. Related behavioral correlates are suggested to be relevant for smoking initiation and maintenance.

Copyright © 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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