Vaccine. 2010 Nov 3;28(47):7460-7. Epub 2010 Sep 25.

Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case-control study.

Puig-Barberà J, Arnedo-Pena A, Pardo-Serrano F, Tirado-Balaguer MD, Pérez-Vilar S, Silvestre-Silvestre E, Calvo-Mas C, Safont-Adsuara L, Ruiz-García M; Surveillance and Vaccine Evaluation Group during the autumn 2009 H1N1 pandemic wave in Castellón, Spain.

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Teruel G, Velázquez-Puig M, Bellido-Blasco JB, Romeu-García MÁ, Herrero-Carot C, Meseguer-Ferrer N, Gil-Fortuño M, Holguin-Gómez R, Orts-Sanchis MJ, Rodrigo-Bartual V, Larrea-González R, Rufino-Bey R, Cuenca-Robles R, Tena-Beltrán R, Jiménez-Marcos R.

Source

Health Promotion Unit, Centro de Salud Pública, Avda del Mar, 12, 12003 Castellón, Spain. jpuigb@terra.es

Abstract

We estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castellón, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147 (44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations.

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Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case-control study.

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