[Transcriptional regulator of carbon catabolite repression CreA in filamentous fungus]

Mol Biol (Mosk). 2010 Jul-Aug;44(4):677-87.
[Article in Russian]

Abstract

Penicillium canescens strain F178 is a natural producer of beta-galactosidase and endo-1,4-beta-xylanase. Tanscription of genes bgaS and xylA coding for these proteins is subject to carbon catabolite repression which proceed mainly in filamentous fungi by transcriptional repressor CreA. creA gene of P. canescens was cloned. It was demonstrated that creA transcription is also subject to carbon catabolite repression. CreA protein remains intranuclear independently of nature of carbon source and glucose concentration in culture medium. In vitro experiments confirm availability of four CreA-binding sites in bgaS promoter, four sites in xylA promoter and one such site in creA promoter.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / metabolism*
  • Endo-1,4-beta Xylanases / biosynthesis
  • Endo-1,4-beta Xylanases / genetics
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation, Enzymologic / physiology
  • Gene Expression Regulation, Fungal / physiology*
  • Penicillium / genetics
  • Penicillium / metabolism*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Transcription, Genetic / physiology*
  • beta-Galactosidase / biosynthesis
  • beta-Galactosidase / genetics

Substances

  • Fungal Proteins
  • Repressor Proteins
  • Carbon
  • beta-Galactosidase
  • Endo-1,4-beta Xylanases