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Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun;3(3):255-68. doi: 10.1002/wsbm.118. Epub 2010 Sep 24.

Functional protein microarray technology.

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  • 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Functional protein microarrays are emerging as a promising new tool for large-scale and high-throughput studies. In this article, we review their applications in basic proteomics research, where various types of assays have been developed to probe binding activities to other biomolecules, such as proteins, DNA, RNA, small molecules, and glycans. We also report recent progress of using functional protein microarrays in profiling protein post-translational modifications, including phosphorylation, ubiquitylation, acetylation, and nitrosylation. Finally, we discuss potential of functional protein microarrays in biomarker identification and clinical diagnostics. We strongly believe that functional protein microarrays will soon become an indispensible and invaluable tool in proteomics research and systems biology.

Copyright © 2010 John Wiley & Sons, Inc.

PMID:
20872749
[PubMed - indexed for MEDLINE]
PMCID:
PMC3044218
Free PMC Article
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