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Mol Biosyst. 2010 Nov;6(11):2129-32. doi: 10.1039/c0mb00063a. Epub 2010 Sep 27.

Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a β-glucosidase in Saccharomyces cerevisiae.

Author information

  • 1Energy Biosciences Institute, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, 600 S. Mathews Ave., Urbana IL 61801, USA.

Abstract

Glucose repression is one of the main limitations in mixed lignocellulosic sugar fermentation for cost-effective production of fuels and chemicals. Here we report a novel strategy to overcome glucose repression by co-expressing a cellobiose transporter and a β-glucosidase in an engineered d-xylose-utilizing Saccharomyces cerevisiae strain. The resulting strain can simultaneously utilize cellobiose and d-xylose for ethanol production.

PMID:
20871937
[PubMed - indexed for MEDLINE]
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