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Indian J Pharmacol. 2010 Jun;42(3):142-5. doi: 10.4103/0253-7613.66835.

Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats.

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  • 1Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.

Abstract

OBJECTIVE:

To study the effect of saturated fatty acid (SFA)-rich dietary vegetable oils on the lipid profile, endogenous antioxidant enzymes and glucose tolerance in type 2 diabetic rats.

MATERIALS AND METHODS:

Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rats. Twenty-eight-day-old normal (N) and diabetic (D) male Wistar rats were fed for 45 days with a fat-enriched special diet (10%) prepared with coconut oil (CO) - lauric acid-rich SFA, palm oil (PO) - palmitic acid-rich SFA and groundnut oil (GNO) - control (N and D). Lipid profile, endogenous antioxidant enzymes and oral glucose tolerance tests were monitored.

RESULTS:

D rats fed with CO (D + CO) exhibited a significant decrease in the total cholesterol and non-high-density lipoprotein cholesterol. Besides, they also showed a trend toward improving antioxidant enzymes and glucose tolerance as compared to the D + GNO group, whereas D + PO treatment aggravated the dyslipidemic condition while causing a significant decrease in the superoxide dismutase levels when compared to N rats fed with GNO (N + GNO). D + PO treatment also impaired the glucose tolerance when compared to N + GNO and D + GNO.

CONCLUSION:

The type of FA in the dietary oil determines its deleterious or beneficial effects. Lauric acid present in CO may protect against diabetes-induced dyslipidemia.

KEYWORDS:

Antioxidant enzymes; atherogenicity; coconut oil; glucose tolerance; palm oil; saturated fatty acid

PMID:
20871763
[PubMed]
PMCID:
PMC2937313
Free PMC Article

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