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Nat Rev Immunol. 2010 Oct;10(10):735-44. doi: 10.1038/nri2850.

The immune system and the gut microbiota: friends or foes?

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  • 1Institut National de la Santé et de la Recherche Médicale (INSERM) U989, Université Paris Descartes, 75730 Paris Cedex 15, France. nadine.cerf-bensussan@inserm.fr

Abstract

The mammalian intestine is home to a complex community of trillions of bacteria that are engaged in a dynamic interaction with the host immune system. Determining the principles that govern host-microbiota relationships is the focus of intense research. Here, we describe how the intestinal microbiota is able to influence the balance between pro-inflammatory and regulatory responses and shape the host's immune system. We suggest that improving our understanding of the intestinal microbiota has therapeutic implications, not only for intestinal immunopathologies but also for systemic immune diseases.

PMID:
20865020
[PubMed - indexed for MEDLINE]
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