Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cerebrospinal Fluid Res. 2010 Sep 22;7:15. doi: 10.1186/1743-8454-7-15.

Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus.

Author information

  • 1Kids Neurosurgical Research Unit, Institute of Neuroscience and Muscle Research, Kids Research Institute, Children's Hospital at Westmead, Hawkesbury Rd, Westmead NSW 2145, Australia. brian@sydneyneurosurgeon.com.au.

Abstract

The discovery of a family of membrane water channel proteins called aquaporins, and the finding that aquaporin 1 was located in the choroid plexus, has prompted interest in the role of aquaporins in cerebrospinal fluid (CSF) production and consequently hydrocephalus. While the role of aquaporin 1 in choroidal CSF production has been demonstrated, the relevance of aquaporin 1 to the pathophysiology of hydrocephalus remains debated. This has been further hampered by the lack of a non-toxic specific pharmacological blocking agent for aquaporin 1. In recent times aquaporin 4, the most abundant aquaporin within the brain itself, which has also been shown to have a role in brain water physiology and relevance to brain oedema in trauma and tumours, has become an alternative focus of attention for hydrocephalus research. This review summarises current knowledge and concepts in relation to aquaporins, specifically aquaporin 1 and 4, and hydrocephalus. It also examines the relevance of aquaporins as potential therapeutic targets in hydrocephalus and other CSF circulation disorders.

PMID:
20860832
[PubMed]
PMCID:
PMC2949735
Free PMC Article

Images from this publication.See all images (8)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk