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Diagn Pathol. 2010 Sep 22;5:62. doi: 10.1186/1746-1596-5-62.

A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases.

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  • 1Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison #300 Chicago, IL, 60612, USA.


Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis. The majority are treated by aggressive curettage or resection. Vascular invasion outside the boundary of the tumor can be seen. Metastasis, with identical morphology to the primary tumor, occurs in a few percent of cases, usually to the lung. On occasion GCTs of bone undergo frank malignant transformation to undifferentiated sarcomas. Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT.

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