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J Cell Biol. 2010 Sep 20;190(6):949-51. doi: 10.1083/jcb.201008116.

Bone matrix to growth factors: location, location, location.

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  • 1Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Daniel.Rifkin@nyumc.org

Abstract

The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)-β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003089) advance this concept by demonstrating how fibrillin-1 and -2 regulate TGF-β and bone morphogenetic protein (BMP) action during osteoblast maturation.

PMID:
20855500
[PubMed - indexed for MEDLINE]
PMCID:
PMC3101590
Free PMC Article
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