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Clin Gastroenterol Hepatol. 2010 Dec;8(12):1002-12. doi: 10.1016/j.cgh.2010.08.024. Epub 2010 Sep 17.

Liver disease in the HIV-infected individual.

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  • 1Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA. jcohen@jhmi.edu

Abstract

Since the advent of effective antiretroviral therapy (ART) for human immunodeficiency virus-1 (HIV), there has been a substantial decrease in deaths related to acquired immunodeficiency syndrome (AIDS). However, in the ART era, liver disease is now the most common non-AIDS-related cause of death among HIV-infected patients, accounting for 14%-18% of all deaths in this population and almost half of deaths among hospitalized HIV-infected patients. Just as the burden of non-AIDS morbidity and mortality has changed in the ART era, the types of liver disease the clinician is likely to encounter among these patients have changed as well. This review will discuss the causes of liver disease in the HIV-infected population in the ART era, including chronic hepatitis C virus, chronic hepatitis B virus, medication-related hepatotoxicity, alcohol abuse, nonalcoholic fatty liver disease, and AIDS-related liver diseases.

Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.

PMID:
20851211
[PubMed - indexed for MEDLINE]
PMCID:
PMC2997131
Free PMC Article
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