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Pediatr Blood Cancer. 2010 Dec 1;55(6):1198-200. doi: 10.1002/pbc.22776.

Multicentric castleman disease in a child with primary immunodeficiency.

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  • 1Division of Allergy and Clinical Immunology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.


Multicentric Castleman disease is a rare lymphoproliferative disorder mostly seen in adults with HIV. It presents with fever and systemic symptoms and is extremely uncommon in children. We describe a novel case of multicentric Castleman disease associated with primary immunodeficiency (common variable immunodeficiency) and discuss pathophysiologic mechanisms and recent advances in understanding this disease.

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