Format

Send to

Choose Destination
See comment in PubMed Commons below
Middle East Afr J Ophthalmol. 2010 Jul;17(3):217-23. doi: 10.4103/0974-9233.65498.

Molecular pathology of retinoblastoma.

Author information

  • 1Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Abstract

Retinoblastoma (RB) is an embryonic neoplasm of retinal origin. For many years, scientists have sought the fundamental origins of tumorigenesis, with the ultimate hope of discovering a cure. Indeed, these efforts have led to a significant understanding that multiple molecular and genetic aberrations, such as uncontrolled proliferation and the inhibition of apoptosis that contribute to the canonical characteristics of tumor biology. Despite these advances, a thorough understanding, such as the precise cells, which are the targets of neoplastic transformation, especially in solid tumors, is currently lacking. The focus of this review is to emphasize the molecular defects involved in the RB tumor progression and mechanisms associated with inhibition of tumor cell apoptotic processes. This review also discusses the importance of target molecules characterization and their potential therapeutic or prognostic use in RB disease.

KEYWORDS:

Pathology; Proteomics; Retinoblastoma; Target Therapy

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk