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Tex Heart Inst J. 2010;37(4):457-60.

Left ventricular rupture due to HIV-associated T-cell lymphoma.

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  • 1Division of Cardiology, University of California, San Francisco 94143, California, USA.


Patients with lymphoma can develop cardiac involvement that includes malignant pericardial effusions and myocardial infiltration, but extensive myocardial invasion by tumor with resultant rupture has been reported only rarely. We report a case of a patient with human immunodeficiency virus and T-cell lymphoma who presented with signs and symptoms that were suggestive of a non-ST-elevation myocardial infarction. Plans were made for cardiac catheterization, but the patient developed thrombocytopenia after the initiation of heparin and eptifibatide. Cardiac catheterization was deferred, and shortly afterwards he had a witnessed cardiac arrest in the hospital and could not be resuscitated. Autopsy revealed transmural infiltration of the myocardium with lymphoma and resultant rupture of the left ventricular free wall. To our knowledge, this is the 1st reported case of left ventricular free-wall rupture due to transmural infiltration by human-immunodeficiency-virus-associated peripheral T-cell lymphoma.We conclude that noncoronary causes of chest pain, including direct myocardial infiltration, should be considered in immunocompromised patients with lymphoma.


Acute coronary syndromes; HIV infections/complications; heart neoplasms/secondary; heart rupture; lymphatic metastasis; lymphoma, AIDS-related; lymphoma, T-cell/pathology; myocardium/pathology; neoplasm invasiveness; pericardium/pathology

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