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Drugs as allergens: an immunoassay for detecting IgE antibodies to cephalosporins.

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  • 1Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia.

Abstract

A radioimmunoassay employing cephalothin linked to a solid phase has been developed for the detection of cephalosporin-reactive IgE antibodies. Direct binding and inhibition studies demonstrated allergenic cross-reactivity between cephalosporins and penicillins, and quantitative hapten inhibition experiments identified the 2-thiophene group, and particularly the attached methylene group, of cephalothin as an allergenic determinant.

PMID:
2083978
[PubMed - indexed for MEDLINE]
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