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Cancer Metastasis Rev. 2010 Dec;29(4):695-707. doi: 10.1007/s10555-010-9254-z.

Perspectives on the mesenchymal origin of metastatic cancer.

Author information

  • 1Department of Medicine, Hematology and Oncology, University of California, San Francisco, San Francisco, CA, USA. leanne.huysentruyt@ucsf.edu

Abstract

Emerging evidence suggests that many metastatic cancers arise from cells of the myeloid/macrophage lineage regardless of the primary tissue of origin. A myeloid origin of metastatic cancer stands apart from origins involving clonal evolution or epithelial-mesenchymal transitions. Evidence is reviewed demonstrating that numerous human cancers express multiple properties of macrophages including phagocytosis, fusogenicity, and gene/protein expression. It is unlikely that the macrophage properties expressed in metastatic cancers arise from sporadic random mutations in epithelial cells, but rather from damage to an already existing mesenchymal cell, e.g., a myeloid/macrophage-type cell. Such cells would naturally embody the capacity to express the multiple behaviors of metastatic cells. The view of metastasis as a myeloid/macrophage disease will impact future cancer research and anti-metastatic therapies.

PMID:
20839033
[PubMed - indexed for MEDLINE]
PMCID:
PMC2962789
Free PMC Article
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