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Nat Rev Genet. 2010 Oct;11(10):665-7. doi: 10.1038/nrg2880. Epub 2010 Sep 14.

Adaptation - not by sweeps alone.

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  • 1Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Illinois 60615, USA.


There has been recent progress in identifying selective sweeps underlying a range of adaptations. Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection.

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