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Clin Nucl Med. 2010 Oct;35(10):824-6. doi: 10.1097/RLU.0b013e3181ef0b31.

Multifocal Langerhans cell histiocytosis with infiltrative pelvic lesions: PET/CT imaging.

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  • 1Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA.


Langerhans cell histiocytosis is essentially a pediatric disorder with a large spectrum encompassing focal lytic osseous eosinophilic granuloma, chronic multifocal Hand-Schuller-Christian lesions, and fulminant disseminated Letterer-Siwe syndrome. However, adult involvement is not uncommon. The authors present a case of multifocal Langerhans cell histiocytosis in a 47-year-old woman. The PET/CT-depicted infiltrative features of soft tissue and osseous pelvic lesions with obstructive uropathy are unusual for this disease.

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