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J Gerontol B Psychol Sci Soc Sci. 2010 Nov;65(6):706-11. doi: 10.1093/geronb/gbq064. Epub 2010 Sep 13.

Propositional density and cognitive function in later life: findings from the Precursors Study.

Author information

  • 1Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Pubic Health, 615 North Wolfe Street, Room E4647, Baltimore, MD 21205, USA. mengelma@jhsph.edu

Abstract

OBJECTIVES:

We used longitudinal data from the Johns Hopkins Precursors Study to test the hypothesis that written propositional density measured early in life is lower for people who develop dementia categorized as Alzheimer's disease (AD). This association was reported in 1996 for the Nun Study, and the Precursors Study offered an unprecedented chance to reexamine it among respondents with different gender, education, and occupation profiles.

METHODS:

Eighteen individuals classified as AD patients (average age at diagnosis: 74) were assigned 2 sex-and-age matched controls, and propositional density in medical school admission essays (average age at writing: 22) was assessed via Computerized Propositional Idea Density Rater 3 linguistic analysis software. Adjusted odds ratios (ORs) for the matched case-control study were calculated using conditional (fixed-effects) logistic regression.

RESULTS:

Mean propositional density is lower for cases than for controls (4.70 vs. 4.99 propositions per 10 words, 1-sided p = .01). Higher propositional density substantially lowers the odds of AD (OR = 0.16, 95% confidence interval = 0.03-0.90, 1-sided p = .02).

DISCUSSION:

Propositional density scores in writing samples from early adulthood appear to predict AD in later life for men as well as women. Studies of cognition across the life course might beneficially incorporate propositional density as a potential marker of cognitive reserve.

PMID:
20837676
[PubMed - indexed for MEDLINE]
PMCID:
PMC2954330
Free PMC Article
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