Cell Tissue Res. 2011 Jan;343(1):189-99. doi: 10.1007/s00441-010-1033-1. Epub 2010 Sep 11.

High-mobility group box 1 (HMGB1) as a master regulator of innate immunity.

Castiglioni A, Canti V, Rovere-Querini P, Manfredi AA.

Source

Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, DIBIT-3A1, Via Olgettina 58, 20132 Milan, Italy.

Abstract

Damage-associated molecular patterns (DAMPs) comprise intracellular molecules characterized by the ability to reach the extracellular environment, where they prompt inflammation and tissue repair. The high-mobility box group 1 (HMGB1) protein is a prototypic DAMP and is highly conserved in evolution. HMGB1 is released upon cell and tissue necrosis and is actively produced by immune cells. Evidence suggests that HMGB1 acts as a key molecule of innate immunity, downstream of persistent tissue injury, orchestrating inflammation, stem cell recruitment/activation, and eventual tissue remodeling.

PMID:: 20835834; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

MeSH Terms

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HMGB1 Protein

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High-mobility group box 1 (HMGB1) as a master regulator of innate immunity.
High-mobility group box 1 (HMGB1) as a master regulator of innate immunity.
Cell Tissue Res. 2011 Jan ;343(1):189-99. doi: 10.1007/s00441-010-1033-1. Epub 2010 Sep 11 .

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