Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2011 Feb;21(1):175-81. doi: 10.1016/j.conb.2010.08.013. Epub 2010 Sep 9.

The dynamic cytoskeleton: backbone of dendritic spine plasticity.

Author information

  • 1Neuroscience Training Program, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA. ewdent@wisc.edu

Abstract

Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super-resolution microscopy indicates that the actin cytoskeleton is more complex and dynamic than originally thought. Also, exciting recent studies from several labs indicate that microtubules, once thought to be restricted to the dendrite shaft, can make excursions into the most distal regions of dendritic spines. Moreover, microtubule invasions of spines appear to be associated with changes in synaptic activity. Thus, it is likely that dynamic interactions between microtubules and actin filaments within dendritic spines play important roles in dendritic spine plasticity.

Copyright © 2010 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk