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Curr Opin Cell Biol. 2010 Oct;22(5):640-50. doi: 10.1016/j.ceb.2010.08.019. Epub 2010 Sep 9.

Cellular mechanisms regulating epithelial morphogenesis and cancer invasion.

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  • 1Department of Cell Biology, Johns Hopkins University, 855 N. Wolfe St, Rangos 452, Baltimore, MD 21205, USA.

Abstract

The cellular mechanisms driving mammalian epithelial morphogenesis are of significant fundamental and practical interest. Historically, these processes have been difficult to study directly, owing to the opacity and relative inaccessibility of mammalian tissues. Recent experimental advances in timelapse imaging and in 3D organotypic culture have enabled direct observation of epithelial morphogenesis. In the mammary gland, branching morphogenesis is observed to proceed through a novel form of collective epithelial migration. The active unit of morphogenesis is a multilayered epithelium with reduced apico-basal polarity, within which cells rearranged vigorously. From within this multilayered state, new ducts initiate and elongate into the matrix without leading cellular extensions or dedicated leaders. We discuss the implications of these findings on our understanding of epithelial morphogenesis in other organs and in cancer progression.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20832275
[PubMed - indexed for MEDLINE]
PMCID:
PMC2948645
Free PMC Article
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