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Science. 2010 Sep 10;329(5997):1353-5. doi: 10.1126/science.1190689.

Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes.

Author information

  • 1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.

Erratum in

  • Science. 2010 Oct 22;330(6003):448.

Abstract

Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.

PMID:
20829487
[PubMed - indexed for MEDLINE]
PMCID:
PMC3510677
Free PMC Article
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