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Biosens Bioelectron. 2010 Oct 15;26(2):333-7. doi: 10.1016/j.bios.2010.08.016. Epub 2010 Aug 19.

Ultrasensitive mycotoxin detection by STING sensors.

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  • 1Department of Biomolecular Engineering, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.

Abstract

Signal transduction by ion nano-gating (STING) technology is a label-free biosensor capable of identifying DNA and proteins. Based on a functionalized quartz nanopipette, the STING sensor includes specific recognition elements for analyte discrimination based on size, shape and charge density. A key feature of this technology is that it does not require any nanofabrication facility; each nanopipette can be easily, reproducibly, and inexpensively fabricated and tailored at the bench, thus reducing the cost and the turnaround time. Here, we show that STING sensors are capable of the ultrasensitive detection of HT-2 toxin with a detection limit of 100 fg/ml and compare the STING capabilities with respect to conventional sandwich assay techniques.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
20829024
[PubMed - indexed for MEDLINE]
PMCID:
PMC2946441
Free PMC Article
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