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Methods Mol Biol. 2010;674:57-83. doi: 10.1007/978-1-60761-854-6_5.

Identification of promoter regions and regulatory sites.

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  • 1Department of Computer Science, Royal Holloway, London, UK.


Promoter sequences are the main regulatory elements of gene expression. Their recognition by computer algorithms is fundamental for understanding gene expression patterns, cell specificity and development. This chapter describes the advanced approaches to identify promoters in animal, plant and bacterial sequences. Also, we discuss an approach to identify statistically significant regulatory motifs in genomic sequences.

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