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J Acquir Immune Defic Syndr. 2010 Dec 15;55(5):615-9. doi: 10.1097/QAI.0b013e3181f4b752.

Association of immunologic and virologic factors with myocardial infarction rates in a US healthcare system.

Author information

  • 1Massachusetts General Hospital, Division of Infectious Diseases, Boston, MA 02114, USA. vtriant@partners.org

Abstract

BACKGROUND:

The effects of immunologic and virologic factors on acute myocardial infarction (AMI) rates in patients with HIV are unclear.

METHODS:

HIV-infected patients in a US healthcare system were assessed for AMI.

RESULTS:

Of 6517 patients with HIV, 273 (4.2%) had an AMI. In a model adjusting for cardiovascular risk factors, antiretroviral medications, and HIV parameters, CD4 count less than 200/mm (odds ratio, 1.74; 95% confidence interval, 1.07 to 2.81; P = 0.02) predicted AMI. Increased HIV viral load was associated with AMI accounting for cardiovascular disease risk factors and antiretroviral medications but was not significant when CD4 count was considered.

CONCLUSIONS:

Immunologic control appears to be the most important HIV-related factor associated with AMI.

PMID:
20827215
[PubMed - indexed for MEDLINE]
PMCID:
PMC3036774
Free PMC Article
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