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AIDS. 2010 Nov 27;24(18):2881-3. doi: 10.1097/QAD.0b013e32833f9fb8.

Is Kaposi's sarcoma occurring at higher CD4 cell counts over the course of the HIV epidemic?

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  • 1Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. nancy.crum@med.navy.mil

Abstract

We evaluated longitudinal rates of Kaposi's sarcoma and trends in CD4 cell counts at the time of Kaposi's sarcoma diagnosis during the HIV epidemic (1985-2008). Although rates of Kaposi's sarcoma have decreased, cases are now occurring at higher CD4 cell counts over time, with more than one-third of cases diagnosed in 2002-2008 occurring at CD4 cell counts of at least 350 cells/μl. These data support future studies evaluating the impact of highly active antiretroviral therapy initiation at higher CD4 cell counts to further reduce Kaposi's sarcoma.

PMID:
20827160
[PubMed - indexed for MEDLINE]
PMCID:
PMC2978255
Free PMC Article
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