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    J Neuroimmunol. 2011 Jan;230(1-2):26-32. Epub 2010 Sep 9.

    T cells that trigger acute experimental autoimmune encephalomyelitis also mediate subsequent disease relapses and predominantly produce IL-17.

    Li J, Zhao X, Hao HW, Shaw MK, Tse HY.

    Source

    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

    Abstract

    Earlier studies showed that donor T cells that initiated a murine adoptive EAE persisted in the CNS of the recipients throughout the subsequent relapsing cycles. To clarify the functions of the persistent donor T cells in EAE relapsing disease, anti-Thy-1 antibodies were used to deplete these cells. Results showed that such treatment abrogated subsequent relapsing cycles in these animals. In addition, it was evident that a shift in cytokine profile occurred during acute and relapsing disease phases. These results unambiguously support the appropriateness of targeting T cells with specificity for the priming antigen in design of therapeutic approaches for MS.

    Copyright © 2010 Elsevier B.V. All rights reserved.

    PMID:
    20826011
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3000891
    Free PMC Article

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