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Laryngoscope. 2010 Oct;120(10):2054-60. doi: 10.1002/lary.21041.

Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window.

Author information

  • 1Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Abstract

OBJECTIVE/HYPOTHESIS:

The distribution of gentamicin in the inner ear via the endolymphatic sac (ES) or round window (RW) routes was investigated.

STUDY DESIGN:

Experimental study.

METHODS:

A fluorescent gentamicin-Texas Red conjugate (GTTR) was adopted to visualize the gentamicin. Adult guinea pigs were treated with GTTR applied to the ES or RW, the animals were allowed to recover for 3 days, then confocal microscopy was used to observe and quantify GTTR distributions in cochlear and vestibular sensory epithelium.

RESULTS:

When GTTR was applied via the ES, strong GTTR labeling was observed in the vestibule while little GTTR was detected in the cochlea (P < .0001). However, distinct GTTR fluorescence was observed in the cochlea and vestibule following RW application (P = .7967). There was less GTTR labeling in cochlea via ES application than through RW administration (P < .0001).

CONCLUSIONS:

ES drug application may be preferable for the treatment of intractable Meniere's disease. Laryngoscope, 2010.

PMID:
20824639
[PubMed - indexed for MEDLINE]
PMCID:
PMC3662803
Free PMC Article

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