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Bioorg Med Chem Lett. 2010 Oct 15;20(20):6061-3. doi: 10.1016/j.bmcl.2010.08.056. Epub 2010 Aug 17.

Synthesis of biologically active biotinylated muramyl dipeptides.

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  • 1Harvard University, Department of Molecular and Cellular Biology, Faculty of Arts and Sciences, Cambridge, MA 02138, USA.


Muramyl dipeptide (MDP) is believed to interact with an innate immune receptor, Nod2. To identify the cellular receptor for MDP, we have synthesized biotinylated MDP isomers and tested the ability of these compounds to activate Nod2 in a cell-based assay. We found that the modification of MDP does not perturb its ability to activate Nod2. These tagged versions of MDP will be useful to identify the cellular receptor of the immunostimulatory molecules.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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