Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2010 Oct;10(10):724-34. doi: 10.1038/nri2835. Epub 2010 Sep 6.

Current perspectives of natural killer cell education by MHC class I molecules.

Author information

  • 1Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.


From the early days of natural killer (NK) cell research, it was clear that MHC genes controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject transplanted allogeneic bone marrow and to kill tumour cells. Although several mechanisms that are involved in this 'education' process have been clarified, most of the mechanisms have still to be identified. Here, we review the current understanding of the processes that are involved in NK cell education, including how the host MHC class I molecules regulate responsiveness and receptor repertoire formation in NK cells and the signalling pathways that are involved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk