Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2010 Dec;22(6):709-14. doi: 10.1016/j.ceb.2010.08.012.

Repression of early zygotic transcription in the germline.

Author information

  • 1Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan. akiran@cdb.riken.jp

Abstract

Germ cells, the progenitors of gametes, are often specified and segregated from somatic lineages early in embryogenesis. As germ cells are essential to create the next generation in sexually reproducing organisms, they must be prevented from differentiating inappropriately into somatic cells. In Drosophila and Caenorhabditis elegans embryos, this is governed by the transient and global repression of mRNA transcription. Furthermore, the inhibition of somatic transcriptional programs is also crucial for germ cell specification in the mouse. Therefore, the active repression of somatic transcriptional programs appears to be a common mechanism for launching the germline. In this review, we will discuss the mechanisms of transcriptional repression during germ cell specification and their interspecies similarities and differences.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20817425
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk