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Mitochondrion. 2011 Jan;11(1):127-35. doi: 10.1016/j.mito.2010.08.010. Epub 2010 Sep 15.

Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies.

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  • 1Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.org

Abstract

The current study evaluated 23 children (ages 2-16 years) with recurrent food intolerance and allergies for CoQ10 deficiency and mitochondrial abnormalities. Muscle biopsies were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain (MRC) activities. Group 2 (age >10 years; n = 9) subjects had significantly decreased muscle CoQ10 than Group 1 (age <10 y; n = 14) subjects (p = 0.001) and 16 controls (p<0.05). MRC activities were significantly lower in Group 2 than in Group 1 (p<0.05). Muscle CoQ10 levels in study subjects were significantly correlated with duration of illness (adjusted r(2) = 0.69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression.

Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

PMID:
20817046
[PubMed - indexed for MEDLINE]
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