Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2010 Sep;203(3):283.e1-17. doi: 10.1016/j.ajog.2010.06.069.

Obesity and diabetes genetic variants associated with gestational weight gain.

Author information

  • 1Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. astuebe@med.unc.edu

Abstract

OBJECTIVE:

We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain.

STUDY DESIGN:

A total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and obesity.

RESULTS:

Among Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele carriers.

CONCLUSION:

We found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain.

Copyright 2010 Mosby, Inc. All rights reserved.

PMID:
20816152
[PubMed - indexed for MEDLINE]
PMCID:
PMC3222335
Free PMC Article

Images from this publication.See all images (7)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk