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Cancer Causes Control. 2010 Dec;21(12):2173-81. doi: 10.1007/s10552-010-9637-z. Epub 2010 Sep 4.

Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women.

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  • 1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. geoffrey.kabat@einstein.yu.edu

Abstract

OBJECTIVE:

To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast.

METHODS:

The association was examined in a cohort of 58,055 postmenopausal women participating in the Women's Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).

RESULTS:

After adjustment for covariates, the hazard ratio for DCIS among women with ≥ 20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70-1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS.

CONCLUSIONS:

Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.

PMID:
20814736
[PubMed - indexed for MEDLINE]
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