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Trends Biochem Sci. 2011 Jan;36(1):19-29. doi: 10.1016/j.tibs.2010.07.008.

RNA helicases at work: binding and rearranging.

Author information

  • Center for RNA Molecular Biology & Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. exj13@case.edu

Abstract

RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of RNA metabolism. These proteins bind or remodel RNA or RNA-protein complexes in an ATP-dependent fashion. How RNA helicases physically perform their cellular tasks has been a longstanding question, but in recent years, intriguing models have started to link structure, mechanism and biological function for some RNA helicases. This review outlines our current view on major structural and mechanistic themes of RNA helicase function, and on emerging physical models for cellular roles of these enzymes.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20813532
[PubMed - indexed for MEDLINE]
PMCID:
PMC3017212
Free PMC Article

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