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Cell. 2010 Sep 3;142(5):682-5. doi: 10.1016/j.cell.2010.08.011.

The language of histone crosstalk.

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  • 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Abstract

It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20813257
[PubMed - indexed for MEDLINE]
PMCID:
PMC3711869
Free PMC Article
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