Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2010 Sep 3;142(5):661-7. doi: 10.1016/j.cell.2010.08.023.

Phosphotyrosine signaling: evolving a new cellular communication system.

Author information

  • 1Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. lim@cmp.ucsf.edu

Abstract

Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20813250
[PubMed - indexed for MEDLINE]
PMCID:
PMC2950826
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk