Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int Rev Neurobiol. 2010;91:173-204. doi: 10.1016/S0074-7742(10)91006-4.

Identifying quantitative trait loci (QTLs) and genes (QTGs) for alcohol-related phenotypes in mice.

Author information

  • 1Department of Behavioral Neuroscience, VA Medical Center and Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

Alcoholism is a complex clinical disorder with genetic and environmental contributions. Although no animal model duplicates alcoholism, models for specific factors, such as the withdrawal syndrome, are useful to identify potential genetic determinants of liability in humans. Murine models have been invaluable to identify quantitative trait loci (QTLs) that influence a variety of alcohol responses. However, the QTL regions are typically large, at least initially, and contain numerous genes, making identification of the causal quantitative trait gene(s) (QTGs) challenging. Here, we present QTG identification strategies currently used in the field of alcohol genetics and discuss relevance to alcoholic human populations.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20813243
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk