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Int Rev Neurobiol. 2010;91:95-128. doi: 10.1016/S0074-7742(10)91004-0.

Using expression genetics to study the neurobiology of ethanol and alcoholism.

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  • 1Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.

Abstract

Recent simultaneous progress in human and animal model genetics and the advent of microarray whole genome expression profiling have produced prodigious data sets on genetic loci, potential candidate genes, and differential gene expression related to alcoholism and ethanol behaviors. Validated target genes or gene networks functioning in alcoholism are still of meager proportions. Genetical genomics, which combines genetic analysis of both traditional phenotypes and whole genome expression data, offers a potential methodology for characterizing brain gene networks functioning in alcoholism. This chapter will describe concepts, approaches, and recent findings in the field of genetical genomics as it applies to alcohol research.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20813241
[PubMed - indexed for MEDLINE]
PMCID:
PMC3427772
Free PMC Article

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